Lacosamide – VimpatR Indication Partial-Onset Seizures Adjunctive therapy Initial: 50 mg PO/IV q12hr Increase by 100 mg/day qWeek Maintenance: 200-400 mg/day PO divided q12hr Mechanism of Action Antiepileptic effects unknown; may slowly inactivate voltage-gated Na channels Binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein that is expressed mainly in the nervous system and is … Continue reading Lacosamide – Vimpat